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Liver Scan

(Liver-Spleen Scan, Liver Scintigraphy)

Procedure overview

What is a liver scan?

A liver scan is a specialized radiology procedure used to examine the liver to identify certain conditions or to assess the function of the liver. A liver scan may also be used to follow the progress of treatment of certain conditions. This procedure may also be referred to as a liver-spleen scan because the spleen often is examined as well due to its proximity and close functional relationship to the liver.

A liver scan is a type of nuclear radiology procedure. This means that a tiny amount of a radioactive substance is used during the procedure to assist in the examination of the liver. The radioactive substance, called a radiopharmaceutical or radioactive tracer, is formed by the addition of a radioactive atom (radionuclide) to a molecule absorbed by normal liver tissue. The remainder of the radioactive substance is absorbed by the spleen and bone marrow.

The radionuclide used in liver scans is usually a form of technetium. Once absorbed into the liver tissue, the radionuclide emits a type of radiation, called gamma radiation. The gamma radiation is detected by a scanner, which processes the information into a picture of the liver.

By measuring the behavior of the radionuclide in the body during a nuclear scan, the doctor can assess and diagnose various conditions, such as tumors, abscesses, hematomas, organ enlargement, or cysts. A nuclear scan may also be used to assess organ function and blood circulation.

The areas where the radionuclide collects in greater amounts are called "hot spots." The areas that do not absorb the radionuclide and appear less bright on the scan image are referred to as "cold spots."

Other related procedures that may be used to diagnose problems of the liver include abdominal X-rays, abdominal ultrasound, computed tomography (CT scan) of the abdomen or liver, or a liver biopsy. Please see these procedures for additional information.

Anatomy of the liver

Illustration of the liver and biliary system
Click to Enlarge

The liver is the largest internal organ in the body. This dark reddish brown organ is located in the upper right side of the abdomen, beneath the diaphragm, and on top of the stomach, right kidney, and intestines.

The wedge-shaped liver consists of 2 main lobes, each made up of thousands of lobules. These lobules are connected to small ducts that connect with larger ducts to ultimately form the hepatic duct. The hepatic duct transports the bile (fluid that helps break down fats and gets rid of wastes in the body) produced by the liver cells to the gallbladder and duodenum (the first part of the small intestine).

The liver carries out many important functions, such as:

  • Making bile. Fluid that helps break down fats and gets rid of wastes in the body

  • Changing food into energy

  • Clearing the blood of drugs and other poisonous substances

  • Producing certain proteins for blood plasma

  • Regulating blood clotting

The spleen, an egg-shaped organ that lies between the stomach and the diaphragm on the left side of the body, helps to keep the blood healthy. The spleen plays a role in the production of lymphocytes (white blood cells that fight infection and disease), destruction of red blood cells, and filtration and storage of blood.

The biliary system consists of the organs and ducts (bile ducts, gallbladder, and associated structures) that are involved in the production and transportation of bile.

Reasons for the procedure

A liver scan may be performed to screen for diseases such as cancer, hepatitis, or cirrhosis. Lesions such as tumors, abscesses, or cysts of the liver or spleen may be seen on a liver scan. A liver scan may be performed to assess the condition of the liver and/or spleen after trauma to the abdomen or when there is unexplained pain in the right upper quadrant of the abdomen. Enlargement of the liver or spleen may be seen on a liver scan.

A liver scan may also be used to assess response to therapy for liver disease and/or to monitor the course of liver disease. Portal hypertension (elevated blood pressure within the liver's circulation) may be detected with a liver scan when more of the radionuclide is absorbed by the spleen rather than the liver.

There may be other reasons for your doctor to recommend a liver scan.

Risks of the procedure

The amount of the radionuclide injected into your vein for the procedure is small enough that there is no need for precautions against radioactive exposure. The injection of the radionuclide may cause some slight discomfort. Allergic reactions to the radionuclide are rare, but may occur.

For some patients, having to lie still on the scanning table for the length of the procedure may cause some discomfort or pain.

Patients who are allergic to or sensitive to medications, contrast dyes, or latex should notify their doctor.

If you are pregnant or suspect that you may be pregnant, you should notify your health care provider due to the risk of injury to the fetus from a liver scan. If you are lactating, or breastfeeding, you should notify your health care provider due to the risk of contaminating breast milk with the radionuclide.

There may be other risks depending on your specific medical condition. Be sure to discuss any concerns with your doctor prior to the procedure.

Certain factors or conditions may interfere with the accuracy of a liver scan. These factors include, but are not limited to, the following:

  • Presence of a radionuclide in the body from a previous nuclear medicine procedure within a certain period of time

  • Barium remaining in the gastrointestinal (GI) tract from a recent barium procedure

Before the procedure

  • Your doctor will explain the procedure to you and offer you the opportunity to ask any questions that you might have about the procedure.

  • You will be asked to sign a consent form that gives your permission to do the procedure. Read the form carefully and ask questions if something is not clear.

  • Generally, no prior preparation, such as fasting or sedation, is required prior to a liver scan, though certain procedures may require a period of fasting. Consult your doctor about to see if this is necessary for your test.

  • Notify the radiologist or technologist if you are allergic to latex and/or sensitive to medications, contrast dyes, or iodine.

  • If you are pregnant or suspect you may be pregnant, you should notify your doctor.

  • Based on your medical condition, your doctor may request other specific preparation.

During the procedure

A liver scan may be performed on an outpatient basis or as part of your stay in a hospital. Procedures may vary depending on your condition and your doctor's practices.

Generally, a liver scan follows this process:

  1. You will be asked to remove any clothing, jewelry, or other objects that may interfere with the procedure.

  2. You will be asked to remove clothing and will be given a gown to wear.

  3. An intravenous (IV) line will be started in the hand or arm for injection of the radionuclide.

  4. The radionuclide will be injected into your vein. The radionuclide will be allowed to concentrate in the liver tissue for approximately 30 minutes.

  5. You will be asked to lie still on a scanning table, as any movement may affect the quality of the scan.

  6. The scanner will be placed over the right upper quadrant of the abdomen in order to detect the gamma rays emitted by the radionuclide in the liver tissue.

  7. You may be repositioned during the scan in order to obtain views of all the surfaces of the liver.

  8. When the scan has been completed, the IV line will be removed.

While the liver scan itself causes no pain, having to lie still for the length of the procedure might cause some discomfort or pain, particularly in the case of a recent injury or invasive procedure such as surgery. The technologist will use all possible comfort measures and complete the procedure as quickly as possible to minimize any discomfort or pain.

After the procedure

You should move slowly when getting up from the scanner table to avoid any dizziness or lightheadedness from lying flat for the length of the procedure.

You may be instructed to drink plenty of fluids and empty your bladder frequently for about 24 hours after the procedure to help flush the remaining radionuclide from your body.

The IV site will be checked for any signs of redness or swelling. If you notice any pain, redness, and/or swelling at the IV site after you return home following your procedure, you should notify your doctor as this may indicate an infection or other type of reaction.

You may resume your usual diet and activities, unless your doctor advises you differently. Your doctor may give you additional or alternate instructions after the procedure, depending on your particular situation.

Online resources

The content provided here is for informational purposes only, and was not designed to diagnose or treat a health problem or disease, or replace the professional medical advice you receive from your doctor. Please consult your health care provider with any questions or concerns you may have regarding your condition.

This page contains links to other websites with information about this procedure and related health conditions. We hope you find these sites helpful, but please remember we do not control or endorse the information presented on these websites, nor do these sites endorse the information contained here.

American Cancer Society

American College of Gastroenterology

National Cancer Institute (NCI)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

National Institutes of Health (NIH)

National Library of Medicine

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